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T - cell Receptor (TCR) Therapy
T - cell Receptor (TCR) Therapy is a form of immunotherapy that involves genetically modifying a patient’s T - cells to express receptors specifically designed to recognize and target cancer cells.

T-Cell Receptor (TCR) Therapy

T-Cell Receptor (TCR) Therapy is a form of immunotherapy that involves genetically modifying a patient’s T cells to express receptors specifically designed to recognize and target cancer cells.

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Our personalized treatment plans evolve with your cancer journey, ensuring that as your needs change, so does the level of care and support we provide. We are committed to empowering you to focus on your recovery, with treatment plans that adapt to meet your unique needs.

  Tailored Assessments

Flexible Treatment Options

Personalized Care Planning

How does T - cell Receptor (TCR) Therapy work?

  1. Collection: T cells are collected from the patient through a biopsy as the first step of the TCR process.
  2. Modification: In the laboratory, the collected T – cells are genetically modified to express T – cell receptors (TCRs) that are specific to antigens found on the patient’s cancer cells.
  3. Expansion: The modified T – cells are then expanded in number to increase their effectiveness.
  4. Infusion: The expanded T – cells are infused back into the patient’s bloodstream.
  5. Targeting Cancer: These TCR-engineered cells seek out and destroy cancer cells that express the specific antigens targeted by the TCRs.

TCR Therapy

T – cell Receptor (TCR) therapy is mutation-specific and can be utilized across various cancer type, provided the targeted mutation is present.

CONDITION OR DISEASE

All types of cancer with KRAS mutation

All types of cancer with P53 mutation

All types of cancer with HRAS mutation

Pancreatic cancer and other solid tumors with mutated GNAS

TARGETED MUTATIONS

G12D, G12V, G12C,G12R,G13D,G12A,G12S

R175h, R248q, R273h, G245, R249, R282, R172

G12V, Q61L,G12S,GL3

G201r, R201c

THERAPY

KRAS THERAPY

P53 TCR THERAPY

HRAS TCR THERAPY

GNAS TCR THERAPY

Benefits

Targeted Approach: TCRs can be engineered to target specific cancer antigens, providing a highly focused treatment.

Potential for High Efficacy: By directing T - cells to attack cancer cells with specific antigens, TCR Therapy can lead to significant tumor reduction.

Adaptability: TCRs can be designed to target a wide range of cancer antigens, making the therapy applicable to various cancers.

Benefits

Targeted Approach: TCRs can be engineered to target specific cancer antigens, providing a highly focused treatment.

Potential for High Efficacy: By directing T cells to attack cancer cells with specific antigens, TCR Therapy can lead to significant tumor reduction.

Adaptability: TCRs can be designed to target a wide range of cancer antigens, making the therapy applicable to various cancers.

Risks and Side-Effects

  • Cytokine Release Syndrome (CRS): A potential side effect characterized by fever, fatigue, and low blood pressure.
  • On-Target, Off-Tumor Toxicity: If the targeted antigen is also present on healthy cells, it could lead to damage to those cells.
  • General Side Effects: May include infusion reactions, infections, and general fatigue.

How is T - cell Receptor (TCR) therapy is different?

  • Target Specificity: TCR Therapy is designed to target specific intracellular antigens presented on cancer cells, unlike CAR-T therapy, which targets surface antigens.
  • Antigen Recognition: TCRs recognize antigens presented by major histocompatibility complex (MHC) molecules, allowing them to target a wider range of antigens.
  • Broader Application: TCR Therapy can potentially be applied to a broader range of cancers compared to other T – cell therapies.

Eligibility Factors

Eligibility depends on factors such as:

  • Type and stage of cancer
  • Presence of specific targetable antigens on the cancer cells
  • Overall health and medical history
  • Previous treatments: A thorough evaluation by a healthcare team is essential to determine if TCR Therapy is a suitable option.

Success Rate

Success rates for TCR Therapy can vary based on cancer type, antigen target, and individual patient factors. Ongoing clinical trials are being conducted to better understand its effectiveness and long-term benefits.

During Therapy

The infusion process is typically performed on an outpatient basis, with close monitoring for potential side effects.

After Therapy

Regular follow-up visits are necessary to monitor for side effects and assess the effectiveness of the treatment.

Recovery

Patients may experience side effects such as fatigue, fever, and immune-related reactions.

Process

Insurance Coverage

Insurance coverage for TCR Therapy varies by provider and plan. Patients should consult with their healthcare provider and insurance company to understand coverage options and potential costs.

Next steps if T - cell Receptor (TCR) Therapy doesn’t work

Alternative options may include:

  • Other immunotherapies
  • Targeted therapies
  • Participation in additional clinical trials.
  • Supportive care to manage symptoms and improve quality of life.

Approved by FDA - Click here for more details

Contact Us

Have questions or need support? We’re here for you. Connect with us today, and let’s work together on a path toward healing and well-being

Contact Information

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  • contact@sunactcancer.com
  • SunAct Cancer Institute Pvt. Ltd. 4th floor,
Tieten Medicity Hospital,
Kasarvadavali, Ghodbunder Road,
Thane (West) - 400615. Maharashtra, India
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  • Phone
    +9186553 13412
  • Toll free
    18002022232

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