Autologous Bone Marrow Transplant

An Autologous Bone Marrow Transplant is a medical procedure in which a patient’s own stem cells are collected, stored, and then reinfused back into their body after high-dose chemotherapy or radiation therapy.

Autologous Bone Marrow Transplant

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How does Autologous Bone Marrow Transplant work?

Collection: Stem cells are collected from the patient (autologous). This can be done through peripheral blood after mobilization.
Conditioning: The patient undergoes conditioning therapy, which includes high doses of chemotherapy and/or radiation to eliminate the diseased bone marrow.
Transplantation: The healthy stem cells are infused into the patient’s bloodstream, where they migrate to the bone marrow and begin to produce new blood cells.
Engraftment: The transplanted stem cells engraft in the bone marrow, where they start producing healthy blood cells.

Target Cancers

Autologous Bone Marrow Transplant is primarily used to treat:

Lymphoma
Multiple Myeloma

Risks and Side-Effects

Organ Damage: High-dose chemotherapy or radiation used in conditioning may cause damage to organs like the liver, lungs, and heart.
Infections Risk: Due to the weakened immune system during the recovery phase, there is a higher risk of infections.
Other Side Effects: May include nausea, vomiting, fatigue, and bleeding.

How is Autologous Bone Marrow Transplant unique?

Autologous Bone Marrow Transplant is unique because:

Potential for Complete Cure: Offers a cure for some conditions that other treatments may only manage.
Complex Procedure: Involves a complex process of stem cell collection, conditioning, and transplantation that requires specialized care.

Eligibility Factors

Eligibility depends on factors such as:

Type and Stage of Disease: Certain cancers and blood disorders are more likely to be treated with this therapy.
Previous Treatments: Patients who have not responded to other treatments may be considered for stem cell therapy.

Administration

Collection: Stem cells are collected from the patient.
Conditioning: The patient receives chemotherapy or radiation to prepare the body for the transplant.
Transplantation: The healthy stem cells are infused into the patient.
Post-Transplant Care: The patient is closely monitored for engraftment and potential complications.

Success Rate

Success rates vary depending on the condition being treated, the type of transplant, and individual patient factors. In some cases, it can lead to long-term remission or cure, while in others, it may be less effective. Ongoing clinical trials and research continue to improve outcomes.

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